Intellectual Property


VisionGate, Inc. Intellectual Property Summary

The U.S. Patent and Trademark Office has granted the Company’s most fundamental patents covering the LuCED® lung test and all components of the LuCED test including the automated 3D imaging platform. Our lead investigative pharmaceutical product iloprost for the prevention of lung cancer also has patent and other intellectual property protections. VisionGate intellectual property portfolio includes over 164 patents in 12 countries and the European Patent Office (comprising 38 member states), and more than 16 patents pending.

 

VisionGate’s Notable Issued U.S. Patents (Sampling)

United States Patent No. 6,770,893

Aug. 3, 2004

METHOD AND APPARATUS FOR EMISSION COMPUTED TOMOGRAPHY USING TEMPORAL SIGNATURES
Inventor: Alan C. Nelson
An optical tomographic system is described wherein the localization of secondary emitters within an object of interest can be determined using the temporal signatures of secondary emission arising from the object being illuminated by an external primary source beam that is non-parallel, such as a cone beam, while said beam is moving relative to the object in a controlled manner. A unique set of secondary emitter points can be localized within the object and, when combined with a computed reconstruction of the object from its primary beam projections, can accurately create an image of the secondary emitters in the object. The system would enable the quantitative three-dimensional imaging of fluorescently labeled molecular probes in a biological cell, for example. (20 Claims)

 

United States Patent No. 6,519,355

Feb. 11, 2003

OPTICAL PROJECTION IMAGING SYSTEM AND METHOD FOR AUTOMATICALLY DETECTING CELLS HAVING NUCLEAR AND CYTOPLASMIC DENSITOMETRIC FEATURES ASSOCIATED WITH DISEASE
Inventor: Alan C. Nelson
A system and method for rapidly detecting cells of interest using multi-dimensional, highly quantitative, nuclear and cytoplasmic densitometric features (NDFs and CDFs) includes a flow optical tomography (FOT) instrument capable of generating various optical projection images (or shadowgrams) containing accurate density information from a cell, a computer and software to analyze and reconstruct the projection images into a multi-dimensional data set, and automated feature collection and object classifiers. The system and method are particularly useful in the early detection of cancers such as lung cancer using a bronchial specimen from sputum or cheek scrapings and cervical/ovarian cancer using a cervical scraping; the system can be used to detect rare cells in specimens including blood. (34 claims)

 

United States Patent No. 7,738,945

June 15, 2010

OPTICAL IMAGING OF A THICK SPECIMEN
Inventor: Mark E. Fauver
A system for optical imaging of a thick specimen that permits rapid acquisition of data necessary for tomographic reconstruction of the three-dimensional (3D) image. One method involves the scanning of the focal plane of an imaging system and integrating the range of focal planes onto a detector. The focal plane of an optical imaging system is scanned along the axis perpendicular to said plane through the thickness of a specimen during a single detector exposure. Secondly, methods for reducing light scatter when using illumination point sources are presented. Both approaches yield shadowgrams. This process is repeated from multiple perspectives, either in series using a single illumination/detection subsystem, or in parallel using several illumination/detection subsystems. A set of pseudo-projections is generated, which are input to a three dimensional tomographic image reconstruction algorithm.

 

United States Patent No. 7,907,765

March 15, 2011

FOCAL PLANE TRACKING FOR OPTICAL MICROTOMOGRAPHY
Inventors: Mark E. Fauver and Alan C. Nelson
An optical tomography system comprising: a light source for illuminating an object of interest with a plurality of radiation beams; an object containing tube, wherein when the object of interest is held within the object containing tube it is illuminated by the plurality of radiation beams to produce emerging radiation from the object containing tube; an objective lens, having an optical axis, for scanning the object at a set of viewing angles to generate a set of pseudoprojection images from the emerging radiation, where each pseudoprojection image is produced by integrating a series of images from a series of focal planes integrated along the optical axis for each angle; a detector array located to receive the set of pseudoprojection images; and means for tracking the object of interest responsively to the imaging data, wherein the tracking means comprises means for tracking a pseudoprojection image center.

 

United States Patent No. 6,636,623

Oct. 21, 2003

OPTICAL PROJECTION IMAGING SYSTEM AND METHOD FOR AUTOMATICALLY DETECTING CELLS WITH MOLECULAR MARKER COM-PARTMENTALIZATION ASSOCIATED WITH MALIGNANCY AND DISEASE
Inventors: Alan C. Nelson, Robert W. Webster and Chee-Wui Chu
A system and method for rapidly detecting cells associated with malignancy and disease using molecular marker compartmentalization includes an optical tomography (OT) or a flow optical tomography (FOT) instrument capable of producing various optical projection images (or shadowgrams) containing accurate density information from a cell or cells labeled with tagged molecular probes or stains, a computer and software to analyze and reconstruct the projection images into a multi-dimensional data set, and automated feature collection and object classifiers. The system and method are particularly useful in the early detection of cancers such as lung cancer using cells from sputum or cheek scrapings and cervical/ovarian cancer using a cervical scraping, and the system can be used to detect rare cells in specimens including blood. (32 Claims)

 

United States Patent No. 7,197,355

Mar. 27, 2007

VARIABLE-MOTION OPTICAL TOMOGRAPHY OF SMALL OBJECTS
Inventor: Alan C. Nelson
A method for variable-motion optical tomography (VOT), where motion of an object of interest, such as a cell, has a variable velocity that can be varied on a cell-by-cell basis. Cell velocity is controlled in one example by packing cells into a capillary tube, or any other linear substrate, so that the cells are stationary within the capillary tube, but the capillary tube is translated and rotated mechanically through an optical tomography reconstruction cylinder. The capillary tube motion may advantageously be controlled in a start-and-stop fashion and translated and rotated at any velocity for any motion interval, under the control of a computer program. (26 Claims)

 

United States Patent No. 6,697,508

Feb. 24, 2004

TOMOGRAPHIC RECONSTRUCTION OF SMALL OBJECTS USING A PRIORI KNOWLEDGE
Inventor: Alan C. Nelson
A system and method for three-dimensional (3D) reconstruction of a cell includes adjusting a current set of projection images according to a set of a priori knowledge to produce adjusted projection images, for example, based on probability masks and/or Bayesian analysis of multiple similar objects in the same sample. A reconstruction algorithm processes the adjusted projection images to generate a 3D image. The 3D image is further adjusted according to at least one set of a priori knowledge to generate an adjusted 3D image. Criteria for process completion are applied to determine whether the adjusted 3D image is adequate. Otherwise, a set of pseudo projections are computationally created at the same projection angles as the current set of projection images and then compared to the current set of projection images to produce a set of new projections, wherein the new projections are input again to the reconstruction algorithm and the steps of the method are repeated until the adequacy criteria are met. (22 Claims)

 

United States Patent No. 6,591,003

July 8, 2003

OPTICAL TOMOGRAPHY OF SMALL MOVING OBJECTS USING TIME DELAY AND INTEGRATION IMAGING
Inventors: Chee-Wui Chu and Alan C. Nelson
A system and method for three-dimensional reconstruction of an object of interest moving at a constant velocity. The object of interest is centered. The object of interest is imaged with optical point sources located at multiple projection angles around the object of interest, in cooperation with opposing time delay and integration (TDI) image sensors located at a distance from the objects of interest such that there is no focal plane within the objects of interest during imaging. Each of the TDI sensors has a line transfer rate synchronized to the constant velocity of the objects of interest. (20 Claims)

 

United States Patent No. 6,944,322

Sept. 13, 2005

OPTICAL TOMOGRAPHY OF SMALL OBJECTS USING PARALLEL-BEAM ILLUMINATION AND POST-SPECIMEN OPTICAL MAGNIFICATION
Inventors: Roger H. Johnson and Alan C. Nelson
An optical tomography (OT) system utilizing parallel-beam illumination is disclosed. Detectors are utilized in several projection imaging geometries to obtain multi-perspective data for tomographic image reconstruction of small objects such as biological cells. Magnification is controlled by post-specimen optics. The method permits the optimal use of parallel-beam back projection image reconstruction methods. (56 Claims)

 

United States Patent No. 7,260,253

Aug. 21, 2007

METHOD FOR CORRECTION OF RELATIVE OBJECT-DETECTOR MOTION BETWEEN SUCCESSIVE VIEWS
Inventors: J. Richard Rahn and Alan C. Nelson
An apparatus and method for correction of relative object-detector motion between successive views during optical tomographic imaging in three dimensions. An object of interest is illuminated to produce an image. A lateral offset correction value is determined for the image. An axial offset correction value is determined for the image. The lateral offset correction value and the axial offset correction value are applied to the image to produce a corrected file image. (17 Claims)

 

 

 


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