About Us


About VisionGate

about
VisionGate, Inc., founded by our CEO Dr. Alan Nelson, is a clinical stage oncology pharmaceutical and diagnostics company with a focus on saving lives by developing new products for the early detection and treatment of lung cancer and lung dysplasia.

The foundation for our diagnostics capability is our proprietary Cell-CT™ 3-Dimensional Cell Imaging and Analysis platform that we believe will transform the ability to image and detect abnormal cells. The Cell-CT system, using a process called optical projection tomography, produces isometric, sub-micron resolution 3D images of individual cells with the ability to morphologically recognize over 700 structural biomarkers of normal and abnormal cells. VisionGate is developing the Cell-CT system to improve its ability to identify biosignatures that would classify cells to aid in abnormal cell detection and prediction of disease. The Cell-CT system can process any liquid biopsy specimen. As such, it has the potential to detect a wide range of different cancers and cancer biosignatures. This could aid in identifying potential treatments using targeted pharmaceutical therapies.

The LuCED® lung test is a non-invasive sputum-based test that detects abnormal cells which indicate lung cancer and lung dysplasia. The LuCED test utilizes the Cell-CT system and is in development for the early detection of lung cancer, lung dysplasia, and the assessment of indeterminate pulmonary nodules (IPN). The LuCED test includes CellGazer™, an imaging software tool under development to facilitate cytopathology diagnosis of abnormal cell images detected by the Cell-CT system.

Our lead investigative pharmaceutical product is iloprost and it is currently in clinical development. Our aim is to achieve the reduction of moderate to severe lung dysplasia as measured by the LuCED lung test, and to qualify iloprost as a first-in-class lung cancer chemoprevention treatment. Iloprost, an oral prostacyclin analog, has progressed through an NCI-sponsored Phase 2 clinical trial and demonstrated a statistically significant reduction in bronchial dysplasia1.

In 2016 VisionGate® acquired a worldwide exclusive license to use iloprost for the prevention of cancer. Iloprost importantly extends the VisionGate product portfolio beyond the LuCED lung test into potential chemoprevention with an oncology pharmaceutical therapeutic. The LuCED® lung test is being developed as a companion diagnostic to iloprost and to provide the unique ability to identify patients with lung dysplasia, a pre-cancerous condition.


1Oral Iloprost Improves Endobronchial Dysplasia in Former Smokers, Keith et.al., Cancer Prev Res (Phila). 2011 Jun; 4(6): 793–802

 


This website may contain forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 and made in reliance on the "safe harbor" provisions of said act. Forward-looking statements are based on estimates, projections, beliefs and assumptions of VisionGate® management at the time of such statements and are not guarantees of future performance. Forward-looking statements involve risks and uncertainties in predicting future results and conditions. Actual results could differ materially from those projected in these forward-looking statements due to a variety of factors, including, without limitation, the acceptance by customers of our products, our ability to develop new products cost-effectively, our ability to raise capital in the future, the development by competitors of products using improved or alternative technology, the retention of key employees and general economic conditions. Forward-looking statements are subject to change without notice.

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